Shellfish Immune Mechanism

Last updated on Oct 19, 2023
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Abstract

  • In the study, four c-type lectins were identified and characterized from the manila clam Venerupis philippinarum (designed as VpClec-1, VpClec-2, VpClec-3 and VpClec4 respectively).
  • Multiple alignments and phylogenetic analysis strongly suggested that they were new members of the c-type lectin superfamily.
  • After Vibrio anguillarum challenge, the temporal expression of all c-type lectins transcripts was up-regulated.
  • They displayed broad agglutination and antibacterial activities towards Vibrio harveyi, Vibrio splendidus, Vibrio anguillarum, Enterobacter cloacae and Aeromonas hydrophila.
  • All the results showed that four C-type lectins functioned as pattern recognition receptors (PRRs) with distinct recognition spectrum, and involved in the innate immune responses of manila clams.
research marine biology
Bowen Yang
Bowen Yang
PhD student in Chemistry

Bioinformatics, Metabolomics, Mass Spectrometry.